Publications by authors named "P S Muir"
Non-contact anterior cruciate ligament (ACL) rupture is a common serious orthopaedic disease in humans and dogs. Familial risk has been recognized in both species but interactions between genetic effects and environmental risk are not understood. We investigated ACL rupture heritability, genetic architecture, selection pressure, sharing of risk genes and biological pathways, and polygenic risk score (PRS) prediction of disease risk.
View Article and Find Full Text PDFAntimicrobial resistance (AMR) is an increasing problem worldwide, and new treatment options for bacterial infections are direly needed. Engineered probiotics show strong potential in treating or preventing bacterial infections. However, one concern with the use of live bacteria is the risk of the bacteria acquiring genes encoding for AMR or virulence factors through horizontal gene transfer (HGT), and the transformation of the probiotic into a superbug.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the environmental factors contributing to cruciate ligament rupture (CR) in Labrador Retrievers, a disease influenced by genetics.
- Researchers evaluated dogs with unexpected CR outcomes based on their genetic risk profiles to identify these environmental factors.
- Findings indicate that neutering before 12 months significantly increases the risk of CR, highlighting the importance of informed decisions about neutering age and overall care for these dogs.
Objective: To evaluate the radiation dose to personnel locations during simulated head and limb scans with a novel equine standing CT (sCT) system.
Methods: Measurements were made with the use of a helical fan beam sCT system (Equina; Asto CT Inc). Scatter radiation was measured in different positions in the sCT room to mimic the location of the control operator, horse handler, and lead rope handler during simulated equine head and limb imaging.
Objective: To investigate whether a humeral intracondylar fissure (HIF) alters bone strain in the French Bulldog humerus, we developed a quantitative CT-based 3-D finite element (FE) model for virtual mechanical testing. We hypothesized that higher strains would be seen in the intracondylar region and lateral epicondylar crest if there was a HIF.
Methods: Patient CT scans from 3 (n = 3) French Bulldogs were selected.