Colonic oxygen microbubbles augment systemic oxygenation and CO removal in a porcine smoke inhalation model of severe hypoxia.

Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patients with a reported mortality rate of up to 45%. The present study focuses on the effect of oxygen microbubble (OMB) infusion via the colon in a porcine model of smoke inhalation-induced lung injury.

Magnesium, calcium and zinc [NN'] heteroscorpionate complexes.

A new family of sterically demanding N2N' heteroscorpionate pro-ligands (HC(tBu2pz)2SiMe2N(H)R (R = iPr, tBu, Ph, Xyl)) has been prepared via a straightforward modular synthetic route. An extensive study into the synthesis and characterisation of lithium, magnesium, calcium and zinc complexes supported by both 3,5-tBu and 3,5-Me substituted N2N' ligand families has been conducted. Attempted deprotonation of the pro-ligands with nBuLi afforded the corresponding lithium salts Li{HC(tBu2pz)2SiMe2NR} (R = iPr (1), tBu (2), Ph (3) and Xyl (4)) but air- and thermal-sensitivity limited the yields of these potentially useful precursors; only the sterically encumbered ligand system allowed clean reactivity.

Electronic Delocalization in Two and Three Dimensions: Differential Aggregation in Indium "Metalloid" Clusters.

Reduction of indium boryl precursors to give two- and three-dimensional M-M bonded networks is influenced by the choice of supporting ligand. While the unprecedented nanoscale cluster [In (boryl) ] (with an In @In @In (boryl) concentric structure), can be isolated from the potassium reduction of a bis(boryl)indium(III) chloride precursor, analogous reduction of the corresponding (benzamidinate)In Br(boryl) system gives a near-planar (and weakly aromatic) tetranuclear [In (boryl) ] system.

New Titanium Borylimido Compounds: Synthesis, Structure, and Bonding.

We report a combined experimental and computational study of the synthesis and electronic structure of titanium borylimido compounds. Three new synthetic routes to this hitherto almost unknown class of Group 4 imide are presented. The double-deprotonation reaction of the borylamine HNB(NAr'CH) (Ar' = 2,6-CHPr) with Ti(NMe)Cl gave Ti{NB(NAr'CH)}Cl(NHMe), which was easily converted to Ti{NB(NAr'CH)}Cl(py).

New Scandium Borylimido Chemistry: Synthesis, Bonding, and Reactivity.

We report a combined synthetic, mechanistic, and theoretical study of the first borylimido complex of a rare earth metal, (NacNac)Sc{NB(NAr'CH)} (25, Ar' = 2,6-CHPr, NacNac = Ar'NC(Me)CHC(Me)NCHCHNMe). Thermolysis of the methyl-borylamide (NacNac)Sc(Me){NHB(NAr'CH)} (18) generated transient imide 25 via rate-determining, first-order methane elimination (KIE ≈ 8.7).