COVID-19 Vaccine Hesitancy among Adults in India: A Systematic Review and Meta-analysis.

The global health crisis triggered by the SARS-CoV-2 in 2019, known as the COVID-19 pandemic, prompted vaccination drives worldwide, including in India, to address the crisis. However, vaccine hesitancy remains a significant challenge to achieving vaccination goals. Hence, we conducted a systematic review and meta-analysis during 2021-2023 to estimate the prevalence of COVID-19 vaccine hesitancy among adults in India and identify associated factors.

Proximal Tibial Fracture in Pseudo-Rheumatoid Synovial Chondromatosis: A Case Study.

Introduction: Progressive pseudorheumatoid dysplasia is an autosomal recessively inherited rare disorder with features of growth retardation, multiple joint deformities, and intra-articular loose bodies.

Case Report: This case study is about a 34-year-old man who presented to us following trauma to his right leg. On general assessment, he was short statured with multiple deformities of both upper and lower limbs with local signs suggestive of proximal tibial fracture over his right tibia.

The Journey of an Ankylosed Hip: A 20 Year Long-Term Follow-up of an Hip Arthrodesis using Cobra Plate - The Present Day Relevance.

Introduction: Hip fusion surgeries even though uncommon have shown good functional outcomes in patients and have its own advantages over arthroplasty.

Case Report: In this case report, we present a 62-year-old female, who underwent right hip arthrodesis using Cobra plate when she was 42 years, with a long-term 20 years follow-up, leading a functionally normal life, good patient satisfaction with acceptable quality of life.

Discussion: Although hip fusion can limit the patient's range of motion, it confers the advantage of better and stable fixation, pain relief, and advantage of future conversion to hip arthroplasty if done within accepted limits.

The First Case Report of a Homozygous Consensus Acceptor Splice Variant in the NUP214 Gene Associated With Fetal Hydrops and Arthrogryposis Multiplex.

The gene encodes a nuclear pore complex protein (nucleoporin, 214 kilodaltons) which plays a critical role in messenger RNA export to the cytoplasm and import of substrates from the cytoplasm. Biallelic mutations in the gene have been associated with susceptibility to acute infection-induced encephalopathy type 9 (ILAE9) (Online Mendelian Inheritance in Man (OMIM), 114350), an autosomal recessive disorder. Herein, we describe for the first time, a fetus with hydrops and arthrogryposis multiplex with a homozygous novel consensus splice site variant in the NUP214 gene, chr9:g.

Neurophysiological assessment of cortical motor function: A direct comparison of methodologies.

Objective: Assessment of cortical function with threshold tracking transcranial magnetic stimulation (TT-TMS) has developed as a biomarker to inform disease pathophysiology, particularly in neurodegenerative disease and dementia. At present, a fully integrated testing system does not exist. To advance clinical utility, and to streamline software design to integrate with diagnostic approaches in an outpatient setting, the present series of studies assessed the effects of altering diagnostic paradigms to measure interstimulus interval (ISI) including serial ascending [T-SICIs] and parallel [T-SICIp] methodologies as measures of cortical motor function (the MagXite software).