Identification of a Noxo1 inhibitor by addition of a polyethylene glycol chain.

Reactive oxygen species (ROS) are a heterogeneous group of highly reactive ions and molecules derived from molecular oxygen (O) which can cause DNA damage and lead to skin cancer. NADPH oxidase 1 (Nox1) is a major producer of ROS in the skin upon exposure to ultraviolet light. Functionally, Nox1 forms a holoenzyme complex that generates two superoxide molecules and reduces NADPH.

Acute abdomen following axial torsion of a Giant Meckel's diverticulum in a young male: A case report.

Introduction And Importance: Among Meckel's diverticulum (MD), the 'Giant' category is relatively rare. Most Giant MDs lead to complications such as torsion and diverticulitis.

Presentation Of Case: A 20-year-old South Asian male presented with a three-day history of vomiting and left-sided abdominal pain.

A fatal perforation of the distal ileum from an ingested fish bone: A case report.

Introduction And Importance: Foreign body-induced perforations of the ileum are rare consequences among adults.

Presentation Of Case: This is a case report of a delayed presentation of an ileal perforation and concurrent faecal peritonitis presented as an acute abdomen, resultant from an ingested fishbone, which led to fatality despite urgent laparotomy.

Clinical Discussion: Perforations following ingested foreign bodies are frequently unanticipated clinically, and diagnosed during advanced imaging studies or surgical interventions.