[Activation of adenylyl cyclase in rats testes and ovaries using thienopyrimidine derivatives].

Signaling systems regulated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG) and having LH receptor as a sensor component play an important role in the functioning of the reproductive tissues. The use of LH and hCG in medicine for the treatment of diseases of the reproductive system and in auxiliary reproductive technologies is limited by their high cost, the need to use parenteral administration, and side effects. In recent years there has been the development of low molecular weight agonists of LH receptor that are devoid of these disadvantages and can be administered orally.

Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons.

Terminally postmitotic neurons continue to express many of the kinesin-related proteins known to configure microtubules during mitosis. Drugs that inhibit these kinesins are being developed as anti-cancer agents with the hope that they will inhibit proliferation of tumor cells without having adverse effects on the nervous system. The prototype, termed monastrol, inhibits the kinesin known as Eg5, which is essential for maintaining separation of the half-spindles.

Problems of science in the development of cotton growing in the USSR.

This article considers the development of cotton growing in the USSR as one of the leading branches of agriculture. The production of raw cotton and the yield of cultivated varieties of cotton reached a high level. Further increase in yield and increase in production of raw cotton are accompanied by the need to resolve a number of problems.