Effect of Fibrinogen on Platelet Reactivity Measured by the VerifyNow P2Y12 Assay.

The VerifyNow assay is based upon the ability of activated platelets to cross-link beads coated with fibrinogen. However, fibrinogen is an abundant protein of blood, and therefore it may affect test results by competing with fibrinogen of beads for binding to platelets. To test this assumption, we assessed the influence of artificial alteration of fibrinogen level in blood samples obtained from donors (n = 9) and patients on clopidogrel therapy (n = 8) on the results of the VerifyNow P2Y12 assay.

[Therapy with aspirin: a new look at the old problem].

Aspirin is known to be efficient in secondary prevention of atherothrombosis. However, a considerable number of patients despite daily doses of aspirin still experience and suffer from various cardiovascular complications. In the medical literature this phenomenon was described as <>, however, no well-defined criteria for this notion have been developed as yet.