Ewing Sarcoma of Temporal bone Presentation as Chronic Otitis Media: A rare Clinical Confusion.

Ewing's Sarcoma is type of malignant round cell neoplasm, representing only 1-4% of all ES cases. Temporal bone ES is often confused with chronic otitis media as clinical picture is quite similar i.e.

Rapid Access to Triarylmethanes (TRAMs) Enabled by Direct Electrolysis of Indolizines with Carbonyls.

A fast, scalable, transition metal-free, electrochemical sp geminal functionalization of carbonyls enabled by anodic oxidation of non-prefunctionalized chromone-fused indolizines to access the triarylmethanes (TRAMs) is disclosed for the first time. This momentary electrochemical approach features the use of readily available carbonyls, implantation of the C(sp) center (well-known for dramatically improving biological active potency), a broad substrate scope, and excellent yields of TRAMs with fluorescence properties.

B7-H3 Expression in Breast Cancer and Brain Metastasis.

Brain metastasis is a significant challenge for some breast cancer patients, marked by its aggressive nature, limited treatment options, and poor clinical outcomes. Immunotherapies have emerged as a promising avenue for brain metastasis treatment. B7-H3 (CD276) is an immune checkpoint molecule involved in T cell suppression, which is associated with poor survival in cancer patients.

Electrochemical selective divergent C-H chalcogenocyanation of -heterocyclic scaffolds.

An electrochemical direct selective C-H chalcogenocyanation approach for indolizine derivatives under mild conditions has been described. Cyclic enone-fused, chromone-fused and 2-substituted indolizines possessing EDGs (electron donating groups) and EWGs (electron withdrawing groups) were successfully reacted with NHSCN and KSeCN under electrochemical conditions to provide a wide array of mono and bis-chalcogenocyanate-indolizines in 75-94% yields. In addition, 1-substituted imidazo[1,5-]quinolines were also successfully chalcogenocyanated under the optimized reaction conditions providing a platform for the synthesis of pharmaceutically privileged molecules.

Electrochemical direct C-H mono and bis-chalcogenation of indolizine frameworks under oxidant-free conditions.

Herein, we disclosed a sustainable electrochemical approach for site-selective C-H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks. Diversely functionalized disulfides and diselenides possessing EDGs and EWGs were successfully reacted with a variety of indolizines to directly access sulfenylated/selenylated indolizines in 40-96% yields. A mechanistic radical pathway was also validated with control experiments and cyclic voltammogram data.