Publications by authors named "P S Freemont"
Indolocarbazoles are natural products with a broad spectrum of bioactivity. A distinct feature of indolocarbazole biosynthesis is the modification of the indole and maleimide rings by regioselective tailoring enzymes. Here, we study a new indolocarbazole variant, which is encoded by the acfXODCP genes from Streptomyces venezuelae ATCC 10712.
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- Urinary tract infections (UTIs) significantly contribute to hospitalizations and fatalities among individuals with dementia compared to matched controls and those with diabetes.
- A large study analyzed data from over 2.4 million people aged 50+ in Wales between 2000-2021, finding that UTIs in dementia and diabetes were linked to increased mortality rates, especially in those with both conditions.
- Delayed or untreated UTIs led to a notable increase in the risk of death, with 5.4% of untreated individuals with dementia dying within 60 days after diagnosis, rising to 5.9% for those also having diabetes.
Article Synopsis
- UTIs are common in older adults and especially impact those with dementia, making early detection essential due to barriers in reporting symptoms.
- Researchers tested low-cost home monitoring devices that track activity and physiology to develop an algorithm that predicts UTI risk, using data from over 27,000 person-days of monitoring.
- The developed machine learning model shows promising sensitivity (74.7%) and specificity (87.9%) for identifying UTIs, utilizing key features like bathroom visits and respiratory rates to alert healthcare providers for timely intervention.
Information is the cornerstone of research, from experimental (meta)data and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging laboratory information management systems to transform this large information load into useful scientific findings.
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