Transaminase-Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N-Heterocycles.

Biocatalysis is now a well-established branch of catalysis and the growing toolbox of natural, evolved and designer enzymes is enabling chemistry previously deemed inaccessible. However, most enzyme methodologies have been developed for functional group interconversions, such as the conversion of a ketone to an amine or alcohol, and do not result in the generation of significant 3D molecular complexity. The application of enzyme-triggered reaction cascade methodologies has the potential to transform simple substrates into complex sp3-rich molecules in one step.

Baby Sleep Project Protocol: a realist evaluation of an intervention to reduce preventable infant mortality.

Introduction: In the UK, approximately 300 infants each year die suddenly and unexpectedly, with most deaths remaining unexplained. Population-wide 'Safer Sleep' messages have brought rates down but remaining deaths now predominantly occur within families experiencing poverty. Many of these deaths may be preventable as the majority have known, avoidable risks present.

Patient experiences and discomfort associated with mid-palatal temporary skeletal anchorage devices.

Background: Mid-palatal placement of temporary skeletal anchorage devices (TSADs) has become increasingly popular among clinicians due to high success rates, low associated risk and streamlining and enhanced customization of associated supra-structures. There is however limited patient data in relation to associated experiences and impacts.

Methods: A survey of patients undergoing mid-palatal TSAD insertion was undertaken using a 27-item bespoke questionnaire.

Deaths in children in England from SARS-CoV-2 infection during the first 2 years of the pandemic: a cohort study.

Objective: The aim of this analysis was to describe the epidemiology, demographics and characteristics of children and young people (CYP) who died of SARS-CoV-2 infection in England during the first 2 years of the pandemic.

Design: The cohort investigated in this study is all CYP, born alive at, or after, 22 weeks of gestation, who died before their 18th birthday between 1 February 2020 and 31 March 2022 in England. All cases were reviewed to identify if SARS-CoV-2 probably, or possibly, contributed to death.