With the growing array of challenges humanity has been experiencing since the global pandemic, knowledge workers at all levels of organizations are experiencing a noted increase in the volatility, uncertainty, complexity, and ambiguity (VUCA) conditions of their work and lives. This has brought about significant changes in ways of working and associated ways of being that have become more fragmented and virtual. Disruptive change continues to unfold on many levels of society, from the organizational to the individual level, with multiple and often unintended consequences.
View Article and Find Full Text PDFExquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this receptor in energy metabolism. Here, we demonstrate that mice bearing global- or adipocyte-specific deletion of Ager, the gene encoding RAGE, display superior metabolic recovery after fasting, a cold challenge, or high-fat feeding.
View Article and Find Full Text PDFChemically unique environment of endophytes makes them to have various adaptive mechanisms for survival. One of such mechanisms involves the production of pharmacologically significant plant-specific metabolites. In the present study, 26 endophytic fungi were isolated from stem of Bacopa monnieri (L.
View Article and Find Full Text PDFBackground: India is currently suffering from an epidemic of noncommunicable diseases; it is thus imperative to screen for cardiovascular risk factors in people visiting Primary Health Centers (PHCs). The objective of the study was to measure the amount of undiagnosed hypertension and selected cardiovascular risk factors present among the adult population through opportunistic screening at the PHC.
Methods: A facility-based opportunistic screening program was carried out in a PHC in rural Puducherry.
One hundred and fifty patients were recruited to assess the reliability of a random urinary dipstick for protein compared with 24 hour urine analysis and to determine if a shorter interval of collection is reliable in screening for proteinuria in hypertensive disorders of pregnancy. These patients were instructed in the collection technique of a 24 hour urine sample. Aliquots were taken to represent 6 and 12 hour collections.
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