Publications by authors named "P S Daltro"
Article Synopsis
- This case is notable for being the first known diagnosis of focal dermal hypoplasia using prenatal MRI, which is a type of medical imaging done before birth.
- There is a significant difference in the imaging findings of the skin malformation when comparing prenatal scans to postnatal (after birth) scans.
- The study emphasizes the importance of both prenatal and postnatal assessments for better understanding and managing this condition over time.
Background: Cardiac arrhythmias are the main cause of sudden death due to Chronic Chagasic Cardiomyopathy (CCC). Here we investigated alterations in connexin 43 (Cx43) expression and phosphorylation in cardiomyocytes as well as associations with cardiac arrhythmias in CCC.
Methods: C57Bl/6 mice infected with underwent cardiac evaluations at 6 and 12 months after infection via treadmill testing and EKG.
Pediatric lung infections continue to be a leading cause of pediatric morbidity and mortality. Although both pediatric and general radiologists are familiar with typical lung infections and their imaging findings in children, relatively rare lung infections continue to present a diagnostic challenge. In addition, the advances in radiological imaging and emergence of several new lung infections in recent years facilitated the need for up-to-date knowledge on this topic.
View Article and Find Full Text PDFA multitude of lung disorders ranging from congenital and genetic anomalies to iatrogenic complications can affect the neonate or the infant within the first year of life. Neonatal and infant chest imaging, predominantly by plain radiography and computed tomography, is frequently employed to aid in diagnosis and management; however, these disorders can be challenging to differentiate due to their broad-ranging, and frequently overlapping radiographic features. A systematic and practical approach to imaging interpretation which includes recognition of radiologic patterns, utilization of commonly accepted nomenclature and classification, as well as interpretation of imaging findings in conjunction with clinical history can not only assist radiologists to suggest the diagnosis, but also aid clinicians in management planning.
View Article and Find Full Text PDFArticle Synopsis
- Sickle cell disease (SCD) often leads to vaso-occlusive crises, which can result in severe organ damage including osteonecrosis (ON), affecting up to 50% of SCD patients.
- A study used NMR-based untargeted metabolomics to analyze blood plasma and bone marrow interstitial fluid from SCD patients with osteonecrosis, identifying metabolic changes linked to different disease stages.
- Citrate may serve as a potential biomarker to distinguish SCD patients with and without osteonecrosis, while metabolites like acetate, creatinine, and glucose were associated with various disease stages; however, the study's findings are limited by small sample sizes and lack of validation.