Correction of the slope-intercept method for the measurement of glomerular filtration rate.

Objective: Glomerular filtration rate (GFR) is frequently assessed using the slope-intercept method by fitting a single exponential to plasma samples obtained 2-5 h after injection. The body surface area (BSA)-corrected one-pool clearance (CO,BSA) overestimates true GFR (CT,BSA) because it fails to sample the full plasma curve, and values of CT,BSA are usually estimated from CO,BSA using the Brøchner-Mortensen (BM) equation. An improved equation, CT,BSA=CO,BSA/(1+fBSA×CO,BSA), with fBSA a fixed constant, was proposed by Fleming, but subsequently Jødal and Brøchner-Mortensen (JBM) reported that fBSA varies with BSA.

UK audit of glomerular filtration rate measurement in 2001.

Objective: To investigate the consistency of glomerular filtration rate (GFR) calculation from plasma sampling in the UK.

Methods: Ten patients' data sets from plasma sampling measurements of GFR were distributed throughout the UK. The data included count rates from four samples taken between 2 and 4 h after injection, a diluted sample of injected dose for standardisation, the patient's height, weight, age and sex.

International Scientific Committee of Radionuclides in Nephrourology (ISCORN) consensus on renal transit time measurements.

This report is the conclusion of the international consensus committee on renal transit time (subcommittee of the International Scientific Committee of Radionuclides in Nephrourology) and provides recommendations on measurement, normal values, and analysis of clinical utility. Transit time is the time that a tracer remains within the kidney or within a part of the kidney (eg, parenchymal transit time). It can be obtained from a dynamic renogram and a vascular input acquired in standardized conditions by a deconvolution process.

UK audit of left ventricular ejection fraction estimation from equilibrium ECG gated blood pool images.

Purpose: To examine the variability of results obtained from computer analysis of left ventricular gated blood pool (LVGBP) images by nuclear medicine centres in the UK.

Methods: Twelve data sets of LVGBP images were distributed via commercial software suppliers to nuclear medicine centres in the UK. Two of the data sets were duplicates and three were acquired from the same patient with different total counts in the images.