[The proteolytic and antiproteolytic indices of the duodenal bile in viral hepatitis patients].

Duodenal bile in patients with viral hepatitis is characterized by reduction of the proteolytic and antiproteolytic activity. Relative indices (AP/P) increased in the convalescent period and reduced in chronic course of viral hepatitis. The authors present a scheme of proteolysis of the liver tissue with participation of pancreatic enzymes.

[The bile immunoglobulins and electrolytes of patients with acute and protracted courses of viral hepatitis].

The authors studied the content of G, M, A, serum immunoglobulins and sodium, potassium and calcium electrolytes in the gallbladder bile in 65 patients with acute, protracted and chronic course of viral hepatitis. It was shown that the content and spectrum of bile immunoglobulins depended on the course of viral hepatitis.

[The bile cholate-cholesterol coefficient for assessing the causes of a protracted convalescence in patients with viral hepatitis].

Changes of the content of bile acids, cholate-cholesterol coefficient, bile acid fraction ratios in the bile were assessed in patients with viral hepatitis and chronic cholecystitis. A scheme is proposed for evaluation of bile bladder function considering four states: functional hypocholia, cholecystitis, threat of cholelithiasis. It is shown that in 23-28% protracted convalescence in viral hepatitis and manifested in prolonged blood serum ALAT activity is caused by the presence of subclinical form of cholecystitis.

[Bile protein fractions in patients with viral hepatitis].

A study of bile protein fractions by means of polyacrylamide gel electrophoresis in patients with viral hepatitis revealed changes in the protein fraction range in those with a prolonged course of nonicteric convalescence manifested in an increase of the amylolytic and reduction of proteolytic fractions. It is suggested that enzymatic disorders of the pancreatic function may lead to development "enzymatic" cholecystitis and protracted convalescence of patients with viral hepatitis.

[Determination of the proteolytic and antiproteolytic activity of bile].

Basing on the known methods for measuring the proteolytic and antiproteolytic activities with the use of N-benzoyl-L-arginine-paranitroanilide, a synthetic substrate, the authors suggest measuring the bile proteolytic and antiproteolytic activities with the use of the same reagents. The examined parameters of the bile are calculated according to the formulae that rule out preliminary plotting of calibration curves. The inhibitory activity is expressed in kontrical antitrypsin activity units, the proteolytic one in the amount of paranitro-aniline per unit of time.