Publications by authors named "P Rzehak"
Article Synopsis
- Seasonal variations at birth can influence DNA methylation, which may affect health outcomes over a person’s lifetime.
- A study involving multiple cohorts discovered specific DNA methylation patterns linked to different birth seasons, revealing 26 differentially methylated regions (DMRs) at birth and 32 in childhood.
- Results suggested that geographic latitude plays a role in these associations, linking certain genes to conditions like schizophrenia and asthma, particularly in infants born in higher latitudes (≥50°N).
Article Synopsis
- Research shows that children exhibit sex-specific differences in disease prevalence, onset age, and susceptibility, potentially linked to DNA methylation variations.
- A meta-analysis of 8438 newborns and 4268 older children found significant differences in DNA methylation at nearly 47,000 CpG sites, with males generally showing lower methylation than females.
- The study identified additional methylation sites related to conditions like cancer and psychiatric disorders, emphasizing the role of DNA methylation in understanding health disparities between sexes.
Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.
Clin Nutr
October 2021
Background: Variability in the FADS2 gene, which codifies the Delta-6 Desaturases and modulates the conversion of essential n-3 and n-6 fatty acids into long-chain polyunsaturated fatty acids, might modify the impact of prenatal supplementation with n-3 docosahexaenoic acid (DHA) on neurodevelopment.
Objective: To assess if maternal FADS2 single nucleotide polymorphisms (SNPs) modified the effect of prenatal DHA on offspring development at 5 years.
Design: We conducted a post-hoc interaction analysis of the POSGRAD randomized controlled trial (NCT00646360) of prenatal supplementation with algal-DHA where 1094 pregnant women originally randomized to 400 mg/day of preformed algal DHA or a placebo from gestation week 18-22 through delivery.
Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms are Associated with Children's Processing Speed up to Age 9 Years.
Nutrients
December 2020
Both pre- and early postnatal supplementation with docosahexaenoic acid (DHA), arachidonic acid (AA) and folate have been related to neural development, but their long-term effects on later neural function remain unclear. We evaluated the long-term effects of maternal prenatal supplementation with fish-oil (FO), 5-methyltetrahydrofolate (5-MTHF), placebo or FO + 5-MTHF, as well as the role of fatty acid desaturase () gene cluster polymorphisms, on their offspring's processing speed at later school age. This study was conducted in NUHEAL children at 7.
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- DNA methylation in childhood and adolescence shows significant correlations with body mass index (BMI), suggesting potential early indicators of obesity.
- Analysis involved cord blood and whole blood measurements from up to 4,133 children in various studies, indicating the importance of age-specific patterns in dietary and physical health.
- Findings reveal that as children age, the strength of the associations between DNA methylation and BMI increases, emphasizing the potential for using methylation patterns in obesity prevention strategies.