Publications by authors named "P Ruth"
Article Synopsis
- The sodium-activated potassium channel Slack (KNa1.1) is essential for regulating how excited neurons become, especially in the spinal dorsal horn that deals with pain and itch sensations.
- Research on mice lacking this channel specifically in spinal dorsal horn neurons showed they experienced heightened neuropathic pain after nerve injury but not in inflammatory pain situations.
- Additionally, these mice had an increased tendency to scratch when exposed to certain itch triggers, suggesting that Slack helps moderate both nerve injury-related pain and acute itch sensations.
Article Synopsis
- The study investigates the role of Na+-activated Slack potassium channels in regulating neuronal and cardiovascular activity, particularly during ischemia and reperfusion (I/R) injury.
- Researchers found that Slack channels are essential for K+ currents in cardiomyocytes and help prevent excessive Ca2+ accumulation, which can lead to cell death under low oxygen conditions.
- The findings emphasize Slack's critical role in maintaining ion balance in heart cells, suggesting that its activity may protect against cardiac damage during I/R injuries.
K channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by K expression levels.
Int J Cancer
November 2024
Prognosis of glioblastoma patients is still poor despite multimodal therapy. The highly brain-infiltrating growth in concert with a pronounced therapy resistance particularly of mesenchymal glioblastoma stem-like cells (GSCs) has been proposed to contribute to therapy failure. Recently, we have shown that a mesenchymal-to-proneural mRNA signature of patient derived GSC-enriched (pGSC) cultures associates with in vitro radioresistance and gel invasion.
View Article and Find Full Text PDFVarious disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, K1.1), a potassium channel highly expressed in itch-sensitive sensory neurons, has therapeutic potential for the treatment of itching.
View Article and Find Full Text PDFBackground: This article represents the conclusion of the updated German status report on climate change and health, which was jointly written by authors from over 30 national institutions and organisations. The objectives are (a) to synthesise the options for action formulated in the report, (b) to combine them into clusters and guiding principles, (c) to address the success factors for implementation, and (d) to combine the options for action into target parameters.
Methods: The options for action from the individual contributions of the status report were systematically recorded and categorised (n=236).