Publications by authors named "P Rudnick"
Intrahepatic abscess is an exceedingly rare complication of locoregional therapy for patients with liver cancer. However, in patients who underwent prior hepatobiliary intervention, the incidence of liver abscess increases significantly, causing morbidity and even mortality in such patients. Here, we will review the relative risk of developing a liver abscess after intraarterial and ablative locoregional therapies in patients with liver cancer depending on whether they underwent any kind of prior hepatobiliary procedures that resulted in violation of the Ampulla of Vater.
View Article and Find Full Text PDFUnlabelled: Proteomics has emerged as a powerful tool for studying cancer biology, developing diagnostics, and therapies. With the continuous improvement and widespread availability of high-throughput proteomic technologies, the generation of large-scale proteomic data has become more common in cancer research, and there is a growing need for resources that support the sharing and integration of multi-omics datasets. Such datasets require extensive metadata including clinical, biospecimen, and experimental and workflow annotations that are crucial for data interpretation and reanalysis.
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- - The National Cancer Institute's CPTAC focuses on analyzing tumors using a proteogenomic approach, which combines genomic data with proteomic information to better understand cancer.
- - The consortium has developed a comprehensive dataset that includes genomic, transcriptomic, proteomic, and clinical data from over 1000 tumors across 10 different groups, aimed at enhancing cancer research.
- - The CPTAC team addresses challenges in integrating and analyzing multi-omics data, especially the complexities arising from combining nucleotide sequencing with mass spectrometry proteomics information.
Article Synopsis
- Lung cancer is a major cause of cancer-related deaths and is challenging to treat due to tumor heterogeneity.
- Researchers analyzed the tumor and phosphoproteome from a lung adenocarcinoma patient who survived over seven years with metastatic disease, utilizing advanced techniques for quantifying proteins in tumor samples collected over time.
- They discovered significant differences in protein expression between lung and lymph node metastatic sites, identified specific genetic variants, and found that the CDK12-G879V mutation increased sensitivity to chemotherapy, highlighting potential targets for treatment.
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced large proteomics data sets from the mass spectrometric interrogation of tumor samples previously analyzed by The Cancer Genome Atlas (TCGA) program. The availability of the genomic and proteomic data is enabling proteogenomic study for both reference (i.e.
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