Publications by authors named "P Ruben"
Article Synopsis
- * The ALS drug riluzole works by stabilizing VGSCs in their inactivated state, which suppresses excessive late sodium current (I) and reduces cellular overexcitability.
- * Riluzole's mechanism involves entering the VGSCs through special openings in their structure, allowing for targeted inhibition of I without blocking sodium conduction, which could guide future drug design and potential repurposing of riluzole.
Article Synopsis
- Cannabidiol (CBD) is shown to block various cardiac ion channels, particularly the hyperpolarization-activated cyclic nucleotide-gated channel (HCN4), which is crucial for heart function.
- CBD activates HCN4 channels by changing their activation properties and speeding up their activation kinetics, working through a unique mechanism distinct from known potentiators.
- The study utilized computational modeling to suggest that CBD binds to a specific site on the channel, highlighting its potential as a novel drug for targeting heart rate regulation.
Background: We identified a novel variant, E171Q, in a neonate with very frequent ectopy and reduced ejection fraction which normalized after arrhythmia suppression by flecainide. This clinical picture is consistent with multifocal ectopic Purkinje-related premature contractions (MEPPC). Most previous reports of MEPPC have implicated variants such as R222Q that neutralize positive charges in the S4 voltage sensor helix of the channel protein Na1.
View Article and Find Full Text PDFVoltage-gated sodium channel (Na) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating neuronal action potential firing to reduce excitability in the brain. However, all currently available Na-targeting antiseizure medications nonselectively inhibit the brain channels Na1.
View Article and Find Full Text PDFBackground: The aim of this study is to present the current views of a diverse group of experts on the diagnosis and treatment of Cow's Milk Protein Allergy (CMPA) in children under 2 years of age in Mexico.
Material And Methods: The study, led by a scientific committee of five experts in CMPA, was divided into six phases, including a modified Delphi process. A total of 20 panelists, all of whom were pediatric specialists, participated in administering a comprehensive 38-item questionnaire.