Publications by authors named "P Rotariu"
Article Synopsis
- Castleman disease (CD) is a rare non-cancerous condition that can be unicentric or multicentric (MCD), with MCD leading to serious symptoms due to cytokine issues, particularly involving interleukin-6 (IL-6).
- This study examined the real-world effectiveness of siltuximab, an anti-IL-6 therapy recommended for idiopathic MCD, in treating patients in Greece and Romania from 2017 to 2022.
- Out of 48 patients treated, 71.1% had a response to the treatment, with a 3-year survival rate of 74%, but some patients experienced adverse effects like elevated liver enzymes and anxiety.
Article Synopsis
- * Treatment with hypomethylating agents like azacytidine is common, but patient responses vary, necessitating better understanding through genetic and epigenetic analysis, particularly RNA methylation.
- * Recent research focused on RNA methylation in MDS patients to determine factors that distinguish responders from non-responders to azacytidine, suggesting that analyzing the methylome can provide more accurate prognostic insights for high-grade MDS patients.
Purpose: To describe our experience and operative technique for retroperitoneoscopic nephrectomy for pyonephrosis and to compare the results with those of open surgery.
Patients And Methods: Since October 1998, 23 successful retroperitoneoscopic nephrectomies for pyonephrosis were performed in our institution (Group A). These patients were compared with 23 patients, matched by age, sex, and body weight, who underwent classic lumbotomy for pyonephrosis (Group B).