Publications by authors named "P Rosenberg"
Background: Apathy in Alzheimer's disease (AD) is associated with cognitive impairment, particularly executive functions such as selective attention, making it unclear whether apathy should be a separate treatment target. Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) is the largest and most recent trial assessing apathy and cognition. This analysis assessed whether changes in apathy correlated to changes in various cognitive domains in ADMET 2.
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- The study aimed to evaluate how the COVID-19 pandemic affected the health and access to services for both paid staff and unpaid caregivers of individuals with dementia.
- Questionnaires were distributed among these caregivers across several communities in Miami, Boston, and Baltimore to gather their experiences during the pandemic.
- Results indicated that paid staff experienced higher rates of COVID-19 exposure and health service disruptions, while unpaid caregivers reported more severe depressive symptoms, highlighting the need for tailored support policies for both groups post-pandemic.
Background: Delirium commonly occurs in older adults following surgery; although its pathophysiology is not fully understood, underlying neurodegeneration is a risk factor.
Objective: Examine the association of preoperative levels of markers of neuronal damage, neurofilament light (NfL) and phosphorylated tau (p-tau), with postoperative delirium.
Methods: Preoperative cerebrospinal fluid (CSF) and plasma were obtained from 158 patients undergoing hip fracture repair and enrolled in the clinical trial "A STrategy to Reduce the Incidence of Postoperative Delirium in Elderly Patients.
Alzheimer's disease (AD) is a leading cause of mortality and morbidity among aging populations worldwide. Despite arduous research efforts, treatment options for this devastating neurodegenerative disease are limited. Sleep disturbances, through their link to changes in neural excitability and impaired clearance of interstitial abnormal protein aggregates, are a key risk factor for the development of AD.
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- The text discusses implementing random walks in Hartree-Fock-Bogoliubov wave functions to enhance quantum Monte Carlo methods, particularly for complex pairing scenarios.
- It aims to accommodate systems with finite pairing order parameters, such as Fulde-Ferrell-Larkin-Ovchinnikov pairing and triplet pairing.
- The authors propose using imaginary-time evolution of these states to calculate ground state correlations, moving beyond current approaches, and provide examples to illustrate their method.