HIV-1 protease cleavage site prediction based on two-stage feature selection method.

Knowledge of the mechanism of HIV protease cleavage specificity is critical to the design of specific and effective HIV inhibitors. Searching for an accurate, robust, and rapid method to correctly predict the cleavage sites in proteins is crucial when searching for possible HIV inhibitors. In this article, HIV-1 protease specificity was studied using the correlation-based feature subset (CfsSubset) selection method combined with Genetic Algorithms method.

Effect of community-based interventions on high-risk drinking and alcohol-related injuries.

Context: High-risk alcohol consumption patterns, such as binge drinking and drinking before driving, and underage drinking may be linked to traffic crashes and violent assaults in community settings.

Objectives: To determine the effect of community-based environmental interventions in reducing the rate of high-risk drinking and alcohol-related motor vehicle injuries and assaults.

Design And Setting: A longitudinal multiple time series of 3 matched intervention communities (northern California, southern California, and South Carolina) conducted from April 1992 to December 1996.

Underage drivers are separating drinking from driving.

Objectives: From 1985 to 1995, drivers younger than 21 years experienced a 50% drop in fatal crashes involving alcohol. This study addresses whether the decrease is explained by young drivers' drinking less or by their separating drinking from driving.

Methods: Nighttime roadside surveys were conducted in 3 communities to test drivers' breath and administer questionnaires on drinking practices.

Alcohol consumption measured at roadside surveys and variations in traffic injury crashes.

This analysis examines whether roadside surveys that measure changes in the prevalence of driving after drinking can be used to evaluate the impact of interventions designed to reduce alcohol-related traffic crashes. Using data collected at a roadside survey over a 4-year period in two California communities (N = 33,614), this analysis examines the relationship of BAC and drinks since 5 P.M.

Evaluation of media advocacy efforts within a community trial to reduce alcohol-involved injury. Preliminary newspaper results.

This article examines coverage of alcohol-related topics in local newspapers as applied to a conceptual model of media advocacy being tested in a five-component community trial to reduce alcohol-involved injuries. Based on a literature review of determinants of exposure of newspaper articles, it uses a composite measure that takes into account the likelihood that given articles will be read. This measure is evaluated in terms of the timing of media advocacy training, technical consultation, and resulting media advocacy efforts.