Publications by authors named "P Rodriguez Iglesias"
Purpose: Studies focused on the effects of sellar and/or perisellar (S/PS) meningiomas on pituitary function are scarce. The primary objective of the present study was to determinate the effects that S/PS meningiomas and their treatments have on pituitary function. Also, we described the clinical characteristics and therapeutic outcomes of the cohort of adult Spanish patients.
View Article and Find Full Text PDFBackground And Objective: Currently, the management for pituitary apoplexy (PA) has been promoted toward a more conservative approach, particularly for patients with low-grade PA scores. Our aim was to investigate trends in PA management and compare clinical presentation, therapeutic approaches, and outcomes before and after 2017, additionally to evaluate long-term outcomes in conservatively treated patients.
Methods: Spanish multicenter, retrospective study.
The ability of cells to sense and respond to mechanical forces is crucial for navigating their environment and interacting with neighboring cells. Myosin II and cortexillin I form complexes known as contractility kits (CKs) in the cytosol, which facilitate a cytoskeletal response by accumulating locally at the site of inflicted stress. Here, we present a computational model for mechanoresponsiveness in Dictyostelium, analyzing the role of CKs within the mechanoresponsive mechanism grounded in experimentally measured parameters.
View Article and Find Full Text PDFIntroduction: UVA-UVB increases skin matrix metalloproteinases and breaks down extracellular proteins and fibrillar type 1 collagen, leading to photodamage. Topical application of nicotinamide prevents UV-induced immunosuppression. Several studies have demonstrated the importance of protection against UV.
View Article and Find Full Text PDFArticle Synopsis
- - This article reviews hypopituitarism (HP), a condition where the pituitary gland doesn't produce enough hormones, detailing its causes like tumors, genetic issues, and other factors such as trauma and medications.
- - Diagnosis involves clinical evaluations and hormonal tests, although these tests can have limitations; identifying specific hormonal deficiencies is critical for treatment.
- - Hormone replacement therapy is the main treatment for HP, improving patient quality of life, but awareness of potential interactions among therapies is crucial; ongoing research and a multidisciplinary approach are also highlighted for better management of the disorder.