Skin biopsies to assess response to systemic corticosteroid therapy in early-stage TEN: case report and review of the literature.

Toxic epidermal necrolysis (TEN) is a severe, mucocutaneous, necrolytic reaction to a variety of antigenic stimuli. The use of systemic corticosteroids in the treatment of TEN is controversial because of a lack of randomized, controlled, prospective studies, and because the effects of steroid therapy vary depending on the dosage and time of its administration during the course of TEN. Immediate intervention is crucial, and the response to corticosteroids in early-stage TEN can be difficult to clinically assess.

Is there a special relationship between CD30-positive lymphoproliferative disorders and epidermal proliferation?

The relationship between CD30+ lymphoma and epithelial proliferations is not well defined. CD30+ lymphoma and lymphomatoid papulos (LyP) share immunohistochemical epitopes and some other features. A single case of LyP associated with multiple keratoacanthomas (KAs) was recently reported.

Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature.

A woman noted vesicles and papules on her left upper extremity fifteen years after she underwent mastectomy and received radiation treatment for left breast carcinoma. The vesicles showed clinical and pathologic features of acquired lymphangiectasis. The skin lesions were successfully treated with shave excision followed by electrodesiccation and sequential peristaltic compressions twice daily.

Interferons alpha, beta and gamma therapy of anogenital human papillomavirus infections.

Anogenital condyloma acuminatum (genital warts) is the most commonly diagnosed sexually transmitted viral disease in the United States. At least 14 of the more than 60 types of human papillomaviruses (HPVs) are responsible for condyloma acuminatum. Anogenital condyloma acuminatum has a broad spectrum of manifestations in men and women, including subclinical latent infection, clinically apparent warts, abnormal genital cytology and squamous carcinoma.