Publications by authors named "P Rocheteau"
Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties.
View Article and Find Full Text PDFObjectives: Assessing the therapeutic potential of a novel antimicrobial pseudopeptide, Pep16, both and for the treatment of septic arthritis caused by .
Methods: Seven clinical isolates of (two MRSA and five MSSA) were studied. MICs of Pep16 and comparators (vancomycin, teicoplanin, daptomycin and levofloxacin) were determined through the broth microdilution method.
Article Synopsis
- * The new antimicrobial pseudopeptide Pep16 may enhance colistin's effectiveness and reduce resistance when combined, as shown in lab tests and mouse models.
- * In tests, Pep16 alone was ineffective, but when combined with colistin, it significantly lowered bacterial counts and prevented colistin resistance in a murine peritonitis model.
Article Synopsis
- Sepsis is a serious condition caused by infection that can lead to problems in organs, including making muscles weaker in very sick patients.
- Researchers studied muscle samples from patients with sepsis and compared them to other sick groups to understand the changes happening in the muscles during septic shock.
- They found that certain important processes in the body's energy production and fat breakdown were less active in sepsis patients, which might be causing muscle issues.
Stem cells have the capacity to ensure the renewal of tissues and organs. They could be used in the future for a wide range of therapeutic purposes and are preserved at liquid nitrogen temperature to prevent any chemical or biological activity up to several decades before their use. We show that the cryogenized cells accumulate damages coming from natural radiations, potentially inducing DNA double-strand breaks (DSBs).
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