Obesity-Related Inflammation Reduces Treatment Sensitivity and Promotes Aggressiveness in Luminal Breast Cancer Modulating Oxidative Stress and Mitochondria.

Background: Obesity, characterized by the secretion of several pro-inflammatory cytokines and hormones, significantly increases the risk of developing breast cancer and is associated with poorer outcomes. Mitochondrial and antioxidant status are crucial in both tumor progression and treatment response.

Methods: This study investigates the impact of an ELIT cocktail (17β-estradiol, leptin, IL-6, and TNFα), which simulates the obesity-related inflammation condition in postmenopausal women, using a 3D culture model.

Mechanisms of change in compassion-based programs for medical students.

Medical practice exposes physicians to numerous stressors, leading to high rates of psychological distress and burnout, a problem that begins during medical school. Scientific evidence suggests that promoting compassion among physicians could improve their well-being and promote patient-centered care. However, the mechanisms underlying these benefits remain unclear.

Strategies and goals in Emotion Regulation models: a systematic review.

Introduction: Studies examining the role of Emotion Regulation (ER) do not consistently explain the underlying model or theory they are employing, resulting in a conflation of different strategies and goals within the ER scientific literature. This study aims to conduct a systematic review and conceptual analysis of the primary strategies and goals advocated in the ER models, theories, and frameworks. Furthermore, we explored the distinctions between the prevailing contemporary ER models and classical conceptions of emotional dynamics, such as those proposed by Aristotle, Descartes, and Darwin.

Tumorspheres as In Vitro Model for Identifying Predictive Chemoresistance and Tumor Aggressiveness Biomarkers in Breast and Colorectal Cancer.

Chemoresistance remains a major challenge in the treatment of breast and colorectal cancer. For this reason, finding reliable predictive biomarkers of response to chemotherapy has become a significant research focus in recent years. However, validating in vitro results may be problematic due to the outcome heterogeneity.

Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer.

Background: Early-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there is still a chance of relapse of 3-15% after treatment. The aim of this study was to uncover the distinctive transcriptomic characteristics and monitoring prognosis potential of peritumoral tissue in early-stage cases.