Utility of photon-counting detectors for MV-kV dual-energy computed tomography imaging.

Purpose: High soft-tissue contrast imaging is essential for effective radiotherapy treatment. This could potentially be realized using both megavoltage and kilovoltage x-ray sources available on some therapy treatment systems to perform "MV-kV" dual-energy (DE) computed tomography (CT). However, noisy megavoltage images obtained with existing energy-integrating detectors (EIDs) are a limiting factor for clinical translation.

Patterns of Failure After Definitive Trimodality Therapy for Muscle-Invasive Bladder Cancer.

Background: Real-world outcomes, especially patterns of failure, are limited for patients with muscle-invasive bladder cancer (MIBC) treated with trimodality therapy (TMT). We aim to evaluate patterns of failure after TMT for MIBC in a typical heterogeneous population.

Methods: In the national Veterans Affairs database, patients with urothelial histology, MIBC (T2-4a/N0-3/M0) who underwent definitive intent TMT between 2000-2018.

Multivariate Cluster Point Process to Quantify and Explore Multi-Entity Configurations: Application to Biofilm Image Data.

Clusters of similar or dissimilar objects are encountered in many fields. Frequently used approaches treat each cluster's central object as latent. Yet, often objects of one or more types cluster around objects of another type.

Contrast-to-noise ratio comparison between X-ray fluorescence emission tomography and computed tomography.

Purpose: We provide a comparison of X-ray fluorescence emission tomography (XFET) and computed tomography (CT) for detecting low concentrations of gold nanoparticles (GNPs) in soft tissue and characterize the conditions under which XFET outperforms energy-integrating CT (EICT) and photon-counting CT (PCCT).

Approach: We compared dose-matched Monte Carlo XFET simulations and analytical fan-beam EICT and PCCT simulations. Each modality was used to image a numerical mouse phantom and contrast-depth phantom containing GNPs ranging from 0.