Publications by authors named "P Rischmann"
Article Synopsis
- A French nationwide trial compared high-intensity focused ultrasound (HIFU) with radical prostatectomy (RP) for treating localized prostate cancer, focusing on salvage therapy-free survival (STFS) and other outcomes in 3328 patients from 2015 to 2019.
- HIFU showed similar STFS at 30 months compared to RP, with lower rates of urinary continence deterioration and less significant erectile function decline among HIFU patients, although some limitations like lack of randomization and age differences in groups were noted.
- The study suggests that HIFU is a viable alternative to RP for low- to intermediate-risk prostate cancer with favorable outcomes for urinary and sexual function, indicating
Background: Muscle-invasive bladder cancer (MIBC) and upper urinary tract urothelial carcinoma (UTUC) are molecularly heterogeneous. Despite chemotherapies, immunotherapies, or anti-fibroblast growth factor receptor (FGFR) treatments, these tumors are still of a poor outcome. Our objective was to develop a bank of patient-derived xenografts (PDXs) recapitulating the molecular heterogeneity of MIBC and UTUC, to facilitate the preclinical identification of therapies.
View Article and Find Full Text PDFIntroduction: Artificial urinary sphincter is considered the gold standard of treatment for male urinary incontinence because of intrinsic sphincter deficiency. The objective of our study was to compare the functional results and complications of the penoscrotal and perineal incision for the implantation of artificial urinary sphincter.
Material And Methods: A retrospective, monocentric study comparing the perioperative and long-term results of primary implantation of an artificial urinary sphincter in men, performed by the penoscrotal or the perineal incision, was conducted in a French university hospital.
Purpose: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa patients in order to provide cancer control equivalent to the standard-of-care procedures while reducing morbidities and complications.
View Article and Find Full Text PDFArticle Synopsis
- * Transient senescence can help with healing and prevent cancer, while long-term senescence can contribute to chronic diseases, particularly those affecting the kidneys and urinary tract.
- * The review will cover how senescence works at a molecular level, its effects on renal and urinary tract diseases, and the potential benefits of targeting senescent cells for treatment.