Publications by authors named "P Richaud"
Article Synopsis
- - Cystic fibrosis (CF) results from mutations in the CFTR gene, leading to early lung inflammation (EI) that occurs without bacterial infection, potentially linked to oxidative stress (OX-S) due to imbalances in oxidants and antioxidants.
- - Recent research shows that copper (Cu), an essential trace element, contributes to oxidative stress in bronchial cells, but its specific role in CF-related early inflammation had not been studied before.
- - In experiments with healthy and CF bronchial cells, it was found that CF cells exhibited inflammation independent of CFTR function, with altered mitochondrial activity, increased metal concentrations, and significant associations between elevated copper levels, oxidative stress, and inflammatory responses.
Background: Adjuvant radiotherapy reduces the risk of biochemical progression in prostate cancer patients after radical prostatectomy. We aimed to compare adjuvant versus early salvage radiotherapy after radical prostatectomy, combined with short-term hormonal therapy, in terms of oncological outcomes and tolerance.
Methods: GETUG-AFU 17 was a randomised, open-label, multicentre, phase 3 trial done at 46 French hospitals.
Background: It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a systematic review of randomised controlled trials (RCTs) comparing these radiotherapy approaches.
Methods: We used a prospective framework for adaptive meta-analysis (FAME), starting the review process while eligible trials were ongoing.
Algal photosynthesis converts nitric oxide into nitrous oxide.
Proc Natl Acad Sci U S A
February 2020
Article Synopsis
- Nitrous oxide (NO) is a greenhouse gas made by algae in oceans, but scientists didn't understand how algae produce it.
- Researchers discovered that a green microalga can change NO into a different form using light energy.
- They found that two different proteins help with this process, one working during the day and the other at night, making it important for understanding greenhouse gases in our oceans.
Low-phosphate (Pi) conditions are known to repress primary root growth of Arabidopsis at low pH and in an Fe-dependent manner. This growth arrest requires accumulation of the transcription factor STOP1 in the nucleus, where it activates the transcription of the malate transporter gene ALMT1; exuded malate is suspected to interact with extracellular Fe to inhibit root growth. In addition, ALS3 - an ABC-like transporter identified for its role in tolerance to toxic Al - represses nuclear accumulation of STOP1 and the expression of ALMT1.
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