Publications by authors named "P Rapp"
Article Synopsis
- - Mitochondria are crucial for brain function and their dysfunction is associated with age-related cognitive decline.
- - A study using rats examined if the mitochondrial respiratory capacity changes with cognitive aging, focusing on the frontal cortex.
- - Results showed no significant differences in mitochondrial oxygen consumption or ATP synthase activity between young and aged rats, indicating that mitochondrial function may not be a key factor in cognitive impairment related to aging.
Background: Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechanisms that allow some APOEε4 carriers to maintain normal cognitive functioning in older adulthood.
Methods: APOEε4 carriers and APOEε3 homozygotes enrolled in the Women's Health Initiative Memory Study (WHIMS) from 1996 to 1999 were classified as resilient if they remained cognitively unimpaired beyond age 80, and as non-resilient if they developed cognitive impairment before or at age 80.
Article Synopsis
- - The study assessed the prevalence of endoparasites in dogs and cats in Finland, finding 3.5% in dogs, 3.6% in pet cats, and a staggering 41.3% in shelter cats, indicating significant disparities between household pets and those in shelters.
- - Common parasites in dogs included Toxocara canis (0.9%) and strongylid eggs (1.7%), while Toxocara cati (3.3%) was prevalent in pet cats; shelter cats had higher rates of multiple parasites, including T. cati at 34.8%.
- - The study highlighted that a substantial 31.2% of dogs were dewormed less than once
The cerebellum is involved in higher order cognitive function and is susceptible to age-related atrophy. However, limited evidence has directly examined the cerebellum's role in cognitive aging. To interrogate potential substrates of the relationship between cerebellar structure and memory in aging, here we target the Purkinje cells (PCs).
View Article and Find Full Text PDFEngineering Antigen-Specific Tolerance to an Artificial Protein Hydrogel.
ACS Biomater Sci Eng
April 2024
Artificial protein hydrogels are an emerging class of biomaterials with numerous prospective applications in tissue engineering and regenerative medicine. These materials are likely to be immunogenic due to their frequent incorporation of novel amino acid sequence domains, which often serve a functional role within the material itself. We engineered injectable "self" and "nonself" artificial protein hydrogels, which were predicted to have divergent immune outcomes on the basis of their primary amino acid sequence.
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