[The hemostatic assistance after sub-total or total hepatectomy in the dog (author's transl)].

After subtotal (90%) or total hepatectomy in the dog, coagulation disturbances appear early and exclude survival beyond 40 hours. These disturbances are the result of a fall in the synthesis of coagulation factors, but may also reflect a consumption syndrome. The ensuing clinical finding is an intravascular coagulation which can give way to fibrinolysis.

[Coagulation disturbances after subtotal or total hepatectomy in the dog (author's transl)].

The authors relate 15 cases of blood coagulation disturbances among three groups of animals after 80%, 90% or total hepatectomy. Animals in group I, after 80% hepatectomy, were sacrified between the 10th and 30th postoperative days. Group II animals, with 90% hepatectomy, survived for periods ranging from 18 to 24 hours.

[Metabolic disorders in experimental hepatic insufficiency and parenteral feeding].

Anhepatia is a complete experimental model for the study of metabolic disturbances associated with hepatic insufficiency. The authors report their experience based upon 16 cases of total hepatectomy in the dog. The animals received different types of hepatic assistance : group 1 (2 dogs), carbohydrate assistance (glucose 7 g/kg/24 h) ; group II (2 dogs), carbohydrate and haemostatic assistance : homologous plasma 50 ml/kg body weight per 24 hours previously stored at - 80 degrees C ; group III (2 dogs) same nutrition as in group II, combined with amino acids : leucine 53, 3 mg, isoleucine 46, 6 mg ; valine 53,3 mg alpha-ketonic acid (lg/kg/24 h) ; group IV (10 dogs, same nutrition as in group III, combined with supplements in neuro transmitter precursors : 6 dopa 1,66 mg, 5 hydroxy-tryptophane 2 mg and choline 16, 66 mg/kg/24h.