Publications by authors named "P Ramos-Ibeas"
Article Synopsis
- Scientists studied how a gene called TEAD4 affects early development in different mammals, like cows and rabbits.
- In mice, TEAD4 is really important for making certain cell types, but in the other animals, it didn't seem to be needed for the same process.
- Even though the gene wasn't necessary for some development steps, there were still some changes, like the number of cells in certain areas being lower in cows without TEAD4.
Article Synopsis
- After a blastocyst hatches, ungulate embryos go through a long phase called conceptus elongation, which is a crucial time when embryos can be lost.
- Scientists studied a specific gene called PPARG to see if it is necessary for the development of cattle embryos by creating embryos without this gene and comparing them to normal embryos.
- They found that even without PPARG, the embryos still developed normally through important stages, so PPARG is not essential for their growth.
Massive genotyping in cattle has uncovered several deleterious haplotypes that cause preterm mortality. Holstein haplotype 5 (HH5) is a deleterious haplotype present in the Holstein Friesian population that involves the ablation of the transcription factor B1 mitochondrial (TFB1M) gene. The developmental stage at which HH5 double-carrier (DC, homozygous) embryos or fetuses die remains unknown and this is a relevant information to estimate the economic losses associated with the inadvertent cross between carriers.
View Article and Find Full Text PDFIn Brief: MEK signalling pathway is required for hypoblast differentiation in mouse embryos, but its role in ungulate embryos remains controversial. This paper demonstrates that MEK is required for hypoblast specification in the inner cell mass of the ovine blastocyst and that it plays a role during the hypoblast migration occurring following blastocyst hatching.
Abstract: Early embryo development requires the differentiation of three cell lineages in two differentiation events.
Karyopherins mediate the movement between the nucleus and cytoplasm of specific proteins in diverse cellular processes. Through a loss-of-function approach, we here examine the role of Karyopherin Subunit Alpha 2 () in spermatogenesis. Knockout male mice exhibited reduced body size and sperm motility, increased sperm abnormalities, and led to the dysregulation of testis gene expression and ultimately to infertility.
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