Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway.

Aging represents the gradual accumulation of alterations within an organism over time. The physical and chemical characteristics of our cells gradually change as we age, making it more difficult for our tissues and organs to self-regulate, regenerate, and maintain their structural and functional integrity. AMP- activated protein kinase (AMPK), a well-known sensor of cellular energy status acts as a central regulator of an integrated signalling network that control homeostasis, metabolism, stress resistance, cell survival and autophagy.

Mycosynthesis of silver nanoparticles from endophytic and their antibacterial activity against methicillin-resistant and .

Background: Methicillin-resistant (MRSA) is a drug-resistant and biofilm-forming pathogenic bacteria with severe morbidity and mortality. MRSA showed resistance against currently available antibiotics. Thus, there is an urgent need to develop novel effective treatments with minimal side effects to eliminate MRSA.

Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy.

Background: Phytochemicals possess a wide range of anti-tumor properties, including the modulation of autophagy and regulation of programmed cell death. Autophagy is a critical process in cellular homeostasis and its dysregulation is associated with several pathological conditions, such as cancer, neurodegenerative diseases, and diabetes. In cancer, autophagy plays a dual role by either promoting tumor growth or suppressing it, depending on the cellular context.

Experimental Investigation on Friction Behavior of Selective Laser Sintering Processed Parts.

Selective laser sintering (SLS) is a powder bed fusion additive manufacturing process that uses polymer powders to produce functional parts directly from digital 3D models. SLS supports small- to medium-batch fabrication of customized products for various end-use applications. These parts can be used as tooling to support conventional manufacturing and inspection where mechanical and tribological behaviors are important.