Publications by authors named "P Rainer"
Article Synopsis
- - The study focuses on developing and validating machine learning models to predict major adverse cardiovascular events (MACE) by evaluating their reliability and interpretability across different populations, utilizing data from Brazil and the USA.
- - Eight machine learning algorithms were trained using a balanced dataset and assessed for their predictive performance based on accuracy and ROC curve metrics, with emphasis on Random Forest, which outperformed the others in both internal and external validations.
- - Findings indicate that while Random Forest was the most effective model, Shapley values offered more consistent insights for understanding feature importance compared to LIME during exploratory analyses.
Wien Klin Wochenschr
October 2024
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a common heart disease that makes the heart muscle thicker, and it can be inherited from family.
- In Austria, about 20,000 to 40,000 people might have this condition, but it's often hard to diagnose because it shows up in many different ways.
- Early diagnosis and genetic testing are important to help patients and their families, and new treatments are available that can help without surgery.
Nat Cardiovasc Res
March 2024
Article Synopsis
- * The study revealed that bone morphogenic protein-4 (BMP4) gradients play a crucial role in maintaining cardiac tissue health in both mice and humans with myocarditis.
- * Enhancing BMP signaling by targeting inhibitors gremlin-1 and gremlin-2 reduced inflammation and fibrosis in mouse models, suggesting that this BMP4-gremlin pathway could be a potential treatment for myocardial inflammation.
