Publications by authors named "P ROTH"
Isocitrate dehydrogenase (IDH)-mutant gliomas, comprising both astrocytomas and oligodendrogliomas, represent a distinct group of tumors that pose an interdisciplinary challenge. Addressing the needs of affected patients requires close collaboration among various disciplines, including neuropathology, neuroradiology, neurosurgery, radiation oncology, neurology, medical oncology, and other relevant specialties when necessary. Interdisciplinary tumor boards are central in determining the ideal diagnostic and therapeutic strategies for these patients.
View Article and Find Full Text PDFUltra-Hypofractionated Whole Breast Radiotherapy (U-WBRT) has been proven to be a viable treatment option for breast cancer patients receiving radiation therapy, however, due to its novelty our understanding of its non-clinical benefits is still evolving. With increasing U-WBRT selection during COVID and in rural and regional settings such as the Western New South Wales Local Health District (WNSWLHD), it's important to quantify the savings when compared to other fractionation schedules (e.g.
View Article and Find Full Text PDFHead and neck squamous cell carcinoma (HNSCC) is the 7th most common cancer globally with a 40-50 % survival rate. Although macrophage migration inhibitory factor (MIF) is overexpressed in most solid tumors and promotes tumor growth and invasion, the therapeutic potential of MIF inhibition in HNSCC is yet to be explored. In this study, we investigated the efficacy of CPSI-1306, a small-molecule MIF inhibitor, on HNSCC cell growth and cancer associated signaling pathways in vitro, as well as its impact on T cells in the HNSCC tumor microenvironment in vivo.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to understand the incidence of acute kidney injury (AKI) in patients undergoing aortic valve replacement who also have aortic stenosis and complex coronary artery disease.
- The research involved 1,232 patients and used statistical matching to focus on 40 pairs with similar risk scores, measuring factors like contrast medium use and renal function post-procedure.
- Results showed no significant difference in AKI occurrence between surgical and percutaneous approaches, and AKI did not correlate with long-term mortality, suggesting that while contrast agents can affect kidney function temporarily, they don’t lead to worse outcomes.