Publications by authors named "P R"
Objective: The study aims to identify potential pharmacophore models for targeting beta-catenin, a crucial protein involved in the development of oral squamous cell carcinoma (OSCC), using a combination of herbal compounds and computational approaches.
Methods: Five natural compounds namely Quercetin, Lycopene, Ovatodiolide, Karsil, and Delphinidin were selected based on their reported activity against beta-catenin. Ligand characteristics were analyzed using SwissADME to evaluate drug-likeness, lipophilicity (logP), and bioavailability.
Intraductal papillary neoplasms of the bile duct are rare tumors with fibrovascular stalks arising from the bile duct. It is often difficult to diagnose preoperatively, especially from mucinous cystic neoplasms. The incidence is more common in Asian countries and rare in Western countries.
View Article and Find Full Text PDFIntroduction: Carpal tunnel syndrome (CTS) is the most common compressive neuropathy, often leading to significant impairment, especially in patients with bilateral involvement. When conservative trials fail, surgical options such as open, mini-open, and endoscopic carpal tunnel release are considered. This report highlights the use of single-stage bilateral mini-open carpal tunnel release, emphasizing its efficiency, reduced recovery time, and cost-effectiveness.
View Article and Find Full Text PDFArticle Synopsis
- - A 66-year-old man experienced increasing exertional chest pain, quickly worsening from NYHA class 2 to class 3, prompting medical investigation despite the lack of a clear trigger.
- - ECG results indicated changes typical of Wellens' syndrome, usually linked to serious left anterior descending artery blockages, yet initial checks showed no significant atherosclerosis.
- - Advanced imaging techniques, including coronary angiography and cardiac CT, identified a severe myocardial bridge in the LAD artery, highlighting the need to consider congenital anomalies in cardiac diagnosis and the importance of early recognition for effective treatment.
Boron toxicity is an increasingly serious problem leading to soil degradation and vegetation loss in arid and semi-arid environments worldwide. The soils of solonetzic complexes often display this characteristic. This study aimed to investigate the vertical distribution of hot water soluble-boron (hws-B) in the sodic and agricultural soils of Israna block in Haryana, India.
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