Publications by authors named "P R Tessier"
Tauopathies are neurodegenerative diseases that involve tau misfolding and aggregation in the brain. These diseases, including Alzheimer's disease (AD), are some of the least understood and most difficult to treat neurodegenerative disorders. Antibodies and antibody fragments that target tau oligomers, which are especially toxic forms of tau, are promising options for immunotherapies and diagnostic tools for tauopathies.
View Article and Find Full Text PDFBackground: Interferon gamma‑1b has been proposed to treat critical illness-induced immunosuppression. We aimed to determine the effects on 90-day outcomes and the cost-effectiveness of interferon gamma‑1b compared to placebo in mechanically ventilated critically ill patients.
Methods: A cost-effectiveness analysis (CEA) was embedded in the "PREV-HAP trial", a multicenter, placebo‑controlled, randomized trial, which randomly assigned critically ill adults under mechanical ventilation to receive interferon gamma or placebo.
Article Synopsis
- Antibody variable regions are responsible for binding to specific antigens, but they can also interact non-specifically, affecting the performance of antibody therapeutics in various ways.
- Researchers analyzed over 300,000 antibody sequences to find that the heavy chain mainly determines non-specific interactions due to its properties, such as positive charge and hydrophobicity, which can be assessed using a machine learning model.
- The study identifies key features, particularly those involving tyrosine, that influence both non-specific binding and specific antigen recognition, providing insights for antibody design and understanding molecular immunology.