Unique effect of aspirin on local 15-oxo-eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity.

Background: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.

MXene/Bacterial Cellulose Hybrid Materials for Sustainable Soft Electronics.

This work evaluated bacterial cellulose (BC) as a possible biodegradable soft electronics substrate in comparison to polyethylene terephthalate (PET), while also focusing on evaluating hybrid MXene/BC material as potential flexible electronic sensor. Material characterization studies revealed that the BC material structure consists of nanofibers with diameters ranging from 70 to 140 nm, stacked layer-by-layer. BC samples produced are sensitive to post-treatment with isopropanol resulting in a change of structural and mechanical properties.

Interpretable machine learning for time-to-event prediction in medicine and healthcare.

Time-to-event prediction, e.g. cancer survival analysis or hospital length of stay, is a highly prominent machine learning task in medical and healthcare applications.

Hydrogel Dressing Biomaterial Enriched with Vitamin C: Synthesis and Characterization.

Materials engineering has become an important tool in the field of hydrogel dressings used to treat difficult-to-heal wounds. Hydrogels filled with bioactive substances used as a targeted healing system are worthy of attention. Vitamin C has healing and supporting effects in the treatment of many skin problems.