Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis.

Methylparaben (MP) belongs to the paraben class and is widely used as a preservative in personal care products, medicines, and some foods. MP acts as an endocrine disrupting chemical (EDC) on the hypothalamic-pituitary-thyroid (HPT) axis. However, the effects of MP have not yet been completely elucidated, as published results are scarce and controversial.

An open-source SQL database schema for integrated clinical and translational data management in clinical trials.

Unlocking the power of personalised medicine in oncology hinges on the integration of clinical trial data with translational data (i.e. biospecimen-derived molecular information).

Childhood early oral ageing syndrome: prevalence and association with possible aetiological factors and consequences for the vertical dimension of occlusion: protocol for a cross-sectional study.

Introduction: Childhood early oral ageing syndrome (CEOAS) is a condition involving oral abnormalities resulting from systemic diseases of different origins that are related to the current lifestyle of the paediatric population. Enamel defects associated with intrinsic and extrinsic factors promote the early loss of tooth structure at an accelerated pace, with negative impacts on function, aesthetics and quality of life. The aim of the study is to identify the prevalence of early tooth wear in childhood and its severity using the CEOAS index, which is a tool for the diagnosis of the condition and for epidemiological surveys, involving the investigation of abnormalities of the oral cavity in the paediatric population and possible factors associated with the severity of the condition.

Optical properties and color stability of a translucent zirconia: effects of finishing after grinding.

This study evaluated the effect of grinding and finishing treatments (polishing or glaze) on the color stability, translucency and opalescence of a translucent zirconia (3Y-TZP) after immersion in red wine. Discs (Ø= 12 mm; thickness 0.8 mm) of 3Y-TZP (Zenostar T, Ivoclar AG) were randomly allocated (n= 8) according to the surface treatment factor: Ctrl - as-sintered; Gr - grinding with diamond bur #4219; Gr + Pol - grinding followed by polishing; Gr + Gl - grinding followed by glaze.

Adapting to COVID-19: Insights from Portuguese residents' home-based life.

Background: The COVID-19 pandemic led to widespread lockdowns and remote work and educational practices that have impacted the lives of many families.

Objective: We aimed to investigate how parents and caregivers altered their routines due to online schooling and teleworking, exploring their association with increased anxiety and depression symptoms.

Methods: We conducted an online cross-sectional study and collected data through snowball sampling.