Quantitative assessment of radioactivity losses in the administration of therapeutic doses of [177Lu]Lu-DOTA-TATE and [90Y]Y-DOTA-TATE.

Background: Therapeutic radiopharmaceuticals [¹⁷⁷Lu]Lu-DOTA-TATE and [⁹⁰Y]Y-DOTA-TATE are used in peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. One of the factors determining the efficacy of such therapy is administering the radiopharmaceutical dose to the patients in a way consistent with treatment planning. This paper evaluates the loss of [¹⁷⁷Lu]Lu-DOTA-TATE and [⁹⁰Y]Y-DOTA-TATE and their mixed doses during the administration to the patient either by direct infusion or by gravity method.

To Be or Not To Be Polar: The Ferroelectric and Antiferroelectric Nematic Phases.

We report two new series of compounds that show the ferroelectric nematic, N, phase in which the terminal chain length is varied. The longer the terminal chain, the weaker the dipole-dipole interactions of the molecules are along the director and thus the lower the temperature at which the axially polar N phase is formed. For homologues of intermediate chain lengths, between the non-polar and ferroelectric nematic phases, a wide temperature range nematic phase emerges with antiferroelectric character.

Ferroelectric Nematic-Isotropic Liquid Critical End Point.

A critical end point above which an isotropic phase continuously evolves into a polar (ferroelectric) nematic phase with an increasing electric field is found in a ferroelectric nematic liquid crystalline material. The critical end point is approximately 30 K above the zero-field transition temperature from the isotropic to nematic phase and at an electric field of the order of 10  V/μm. Such systems are interesting from the application point of view because a strong birefringence can be induced in a broad temperature range in an optically isotropic phase.

Chiral columns forming a lattice with a giant unit cell.

Mesogenic materials, quinoxaline derivatives with semi-flexible cores, are reported to form a new type of 3D columnar phase with a large crystallographic unit cell and lattice below the columnar hexagonal phase. The 3D columnar structure is a result of frustration imposed by the arrangement of helical columns of opposite chiralities into a triangular lattice. The studied materials exhibit fluorescence properties that could be easily tuned by modification of the molecular structure; for compounds with the extended π electron conjugated systems the fluorescence is quenched.

Research of Vibrations of an Armoured Personnel Carrier Hull with FE Implementation.

Modern wheeled armoured vehicles can perform a variety of tasks, making the development of weapon systems that can be safely and effectively integrated with the vehicle structure an area of interest. Due to the cost of implementing new models, it is more economical to test potential configurations using numerical methods, such as the finite element method. The numerical model has been validated to confirm the reliability of the obtained results.