Publications by authors named "P R Pfeiffer"
Importance: The effect of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) chemotherapy on overall survival (OS) is unclear because current studies do not account for the number of cycles of preoperative chemotherapy and adjuvant chemotherapy regimen.
Objective: To investigate the association of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX with OS, taking into account the number of cycles of preoperative chemotherapy and adjuvant chemotherapy regimen.
Design, Setting, And Participants: This retrospective cohort study included patients with localized pancreatic adenocarcinoma treated with 2 to 11 cycles of preoperative (m)FOLFIRINOX followed by resection across 48 centers in 20 countries from 2010 to 2018.
Article Synopsis
- Early identification of patients with metastatic colorectal cancer (mCRC) who may not benefit from first-line chemotherapy could guide the timely use of second-line treatments, potentially improving outcomes.
- The study analyzed the relationship between changes in carcinoembryonic antigen (CEA), circulating cell-free DNA (cfDNA), and circulating tumor DNA (ctDNA) during chemotherapy, finding that early ctDNA changes are more predictive of treatment response and survival outcomes than CEA.
- Results indicated that lack of a strong molecular response in ctDNA by the first evaluation was linked to shorter progression-free survival (PFS) and overall survival (OS), highlighting ctDNA's potential as a valuable biomarker in monitoring mCRC treatment.
Objective: This clinical trial investigated the safety and efficacy of single-cycle pembrolizumab in patients with localized deficient mismatch repair (dMMR) colon cancer.
Background: Neoadjuvant immunotherapy has induced remarkable rates of pathological complete response in patients with dMMR colon cancer. However, the optimal length and type of treatment are yet to be determined.
Background: Dashboards have become ubiquitous in health care settings, but to achieve their goals, they must be developed, implemented, and evaluated using methods that help ensure they meet the needs of end users and are suited to the barriers and facilitators of the local context.
Objective: This scoping review aimed to explore published literature on health care dashboards to characterize the methods used to identify factors affecting uptake, strategies used to increase dashboard uptake, and evaluation methods, as well as dashboard characteristics and context.
Methods: MEDLINE, Embase, Web of Science, and the Cochrane Library were searched from inception through July 2020.
Cutibacterium acnes infective endocarditis-an emerging pathogen.
Eur J Cardiothorac Surg
November 2024
Article Synopsis
- * It found that 269 patients (3.1%) had C. acnes endocarditis, primarily affecting younger individuals with native valves, while prosthetic valve cases were more frequent in older age groups.
- * Although survival rates were better for native valve cases, the incidence of C. acnes endocarditis is concerning and requires specialized diagnostic methods, but surgical outcomes were generally acceptable.