Publications by authors named "P R Klatser"
Introduction: MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Their role in the pathophysiology of dementia and potential as biomarkers remains undetermined.
Methods: We conducted a single- (one-by-one) and multi-marker (joint) analysis to identify well-expressed circulating miRNAs in plasma (total = 591) associated with general cognition and incident dementia, for 1615 participants of the population-based Rotterdam Study.
Background: In 2011 the Stepwise Laboratory Quality Improvement Process Towards Accreditation (SLIPTA) was launched, aimed at strengthening the quality and competence of African clinical, public health and reference laboratories. We reviewed the first version of the SLIPTA checklist in 2011. The continued development and publication of a new version of the International Organization for Standardization (ISO) 15189 standard demands a renewed review.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are non-coding RNA molecules that regulate gene expression. Extensive research has explored the role of miRNAs in the risk for type 2 diabetes (T2D) and coronary heart disease (CHD) using single-omics data, but much less by leveraging population-based omics data. Here we aimed to conduct a multi-omics analysis to identify miRNAs associated with cardiometabolic risk factors and diseases.
View Article and Find Full Text PDFContext: Access to internationally controlled essential medicines is a problem worldwide. More than five billion people cannot access opioids for pain and palliative care or do not have access to surgical care or anesthetics, 25 million people living with epilepsy do not have access to their medicines, and 120,000 women die annually owing to postpartum hemorrhage. In Uganda, access to controlled medicines is also problematic, but a lack of data on factors that influence access exists.
View Article and Find Full Text PDFArticle Synopsis
- This study analyzed the epidemiology of extrapulmonary tuberculosis (EPTB) patients in Accra, Ghana, comparing them to pulmonary TB (PTB) patients and identifying key risk factors for mortality among EPTB patients.
- Out of 3,342 new TB patients, 21.8% had EPTB, with higher prevalence in males and common sites including disseminated, pleural, and spinal areas, demonstrating a lower treatment success rate for EPTB compared to PTB (70.1% vs. 84.2%).
- Significant risk factors for EPTB included HIV positivity and female gender, while factors associated with mortality among EPTB patients were older age, HIV status, and central nervous