Publications by authors named "P R K Bhargav"
AlphaMut: A Deep Reinforcement Learning Model to Suggest Helix-Disrupting Mutations.
J Chem Theory Comput
January 2025
Helices are important secondary structural motifs within proteins and are pivotal in numerous physiological processes. While amino acids (AA) such as alanine and leucine are known to promote helix formation, proline and glycine disfavor it. Helical structure formation, however, also depends on its environment, and hence, prior prediction of a mutational effect on a helical structure is difficult.
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- Researchers identified specific enzymes known as cytochrome P450s that are responsible for oxidative modifications of these compounds, revealing their roles in the biosynthetic pathway of triterpenoids.
- The study concluded that the initial oxidation step in this pathway likely involves C-28 modification, with subsequent branching into different hydroxylation processes to create various beneficial compounds.
Background: Yoga therapy (YT) as an adjunct treatment has reportedly been demonstrated to offer clinical benefits in major depressive disorder (MDD). Although a few biological pathways are suggested to mediate the effects of yoga, the precise mechanistic basis remains unknown. Oxidative stress pathway activation has consistently been linked to the pathobiology of MDD.
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- Neuroendocrine neoplasms (NENs) of the gallbladder were studied at a high-volume cancer hospital, focusing on classification and patient outcomes.
- A total of 147 patients were analyzed from 2015 to 2023, revealing a median age of 52 and a predominance of neuroendocrine carcinomas (NECs) that often presented at advanced stages.
- Results indicated that patients receiving multimodality treatment had significantly better overall survival rates compared to those who did not, highlighting the need for improved systemic therapies for better management of these aggressive tumors.