Publications by authors named "P R H Robson"
The maternal-fetal interface has long been considered as a frontier for an evolutionary arms race due to the close juxtaposition of genetically distinct tissues. In hemochorial species with deep placental invasion, including in humans, maternal stroma prepares its defenses against deep trophoblast invasion by decidualization, a differentiation process characterized by increased stromal cell matrix production, and contractile force generation. Decidualization has evolved from an ancestral wound healing response of fibroblast activation by the endometrial stroma.
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- Underserved populations in Canada and globally face serious cancer care inequities due to systemic barriers, which leads to inadequate care and outcomes.
- The study aims to identify effective interventions that improve access to cancer care for these populations in high-income countries and the US, using a systematic review of relevant literature from the past decade.
- Out of 7,549 articles reviewed, 74 studies were included, highlighting seven types of interventions like patient navigation and financial support, primarily addressing issues like language, financial constraints, and geographical access to improve cancer screening and care for targeted groups.
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- The study investigates the effectiveness of [F]FDG PET and LGE-CMR imaging methods for distinguishing cardiac sarcoidosis (CS) from myocardial inflammation resulting from COVID-19.
- It involved analyzing image data from 35 post-COVID-19 patients and 40 CS patients, focusing on extracting and testing radiomic features to improve diagnostic accuracy for these conditions.
- The results indicated that the combined signature of features from [F]FDG PET performed exceptionally well with an AUC of 0.98 and accuracy of 0.91, while LGE-CMR achieved an accuracy of 0.75 and AUC of 0.87, highlighting the potential of machine learning classifiers in enhancing diagnostic outcomes.
Background: F-Fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/magnetic resonance (MR) can identify inflammation and fibrosis, which are high-risk features in cardiac sarcoidosis.
Objective: The purpose of this study was to evaluate whether the involvement of certain myocardial segments is associated with higher risk compared to others.
Methods: One hundred twenty-four patients with suspected clinical sarcoidosis underwent F-FDG-PET/MR.
The use of organoid models in biomedical research has grown substantially since their inception. As they gain popularity among scientists seeking more complex and biologically relevant systems, there is a direct need to expand and clarify potential uses of such systems in diverse experimental contexts. Herein we outline a high-content screening (HCS) platform that allows researchers to screen drugs or other compounds against three-dimensional (3D) cell culture systems in a multi-well format (384-well).
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