Publications by authors named "P R Flatt"
Article Synopsis
- * Plant-based foods are emerging as a beneficial natural alternative for managing T2DM due to their variety of phytochemicals, which can aid in controlling blood sugar levels and support weight management.
- * This review highlights the importance of integrating plant-derived foods into diets for the prevention and management of DM, emphasizing their accessibility, affordability, and minimal side effects compared to traditional medications.
Background: Pancreatic islet β-cell mass expands during pregnancy, but underlying mechanisms are not fully understood. This study examines the impact of pregnancy and cafeteria diet on islet morphology, associated cellular proliferation/apoptosis rates as well as β-cell lineage.
Methods: Non-pregnant and pregnant Ins1;Rosa26-eYFP transgenic mice were maintained on either normal or high-fat cafeteria diet, with pancreatic tissue obtained at 18 days gestation.
Aim: To thoroughly investigate the impact of sustained neuropeptide Y4 receptor (NPY4R) activation in obesity-associated diabetes.
Methods: Initially, the prolonged pharmacodynamic profile of the enzymatically stable pancreatic polypeptide (PP) analogue, [P]PP, was confirmed in normal mice up to 24 h after injection. Subsequent to this, [P]PP was administered twice daily (25 nmol/kg) for 28 days to high-fat-fed mice with streptozotocin-induced insulin deficiency, known as HFF/STZ mice.