The influence of the forest corridors to the north of the Andes on the diversification of the bright-rumped Attila, (Passeriformes, Tyrannidae), during the climatic oscillations of the middle Pleistocene.

This study aims to enhance our understanding of the temporal and spatial processes scales governing the evolutionary diversification of Neotropical birds with Trans- and Cis-Andean populations of the species from South and Central America. Through a multilocus analysis of the mitochondrial (CytB and ND2) and nuclear genes (I7BF, I5BF, and G3PDH) of 41 samples representing six subspecies, we describe the existing molecular lineages of , and estimate their demographic dynamics. We used Ecological Niche Modeling (ENM) with six different algorithms to predict the potential distribution of in both present-day and past scenarios, examining the overlap climatic niche between Cis- and Trans-Andean lineages.

Fourteen weeks of β-alanine supplementation and HIIT did not improve serum BDNF concentrations and Stroop test performance.

This study aimed to investigate whether 14 weeks of β-alanine supplementation and high-intensity intermittent training improves brain-derived neurotrophic factor concentrations and cognitive aspects related to executive functions assessed by the Stroop test. Thirteen healthy and active men underwent a 4-week supplementation period (β-alanine: 6.4 g/d or a placebo) followed by 10-week supplementation combined with high-intensity intermittent training, totaling 14 weeks of intervention.

Cardamonin anticancer effects through the modulation of the tumor immune microenvironment in triple-negative breast cancer cells.

The tumor immune microenvironment (TIME) plays a critical role in cancer development and response to immunotherapy. Immune checkpoint inhibitors aim to reverse the immunosuppressive effects of the TIME, but their success has been limited. Immunotherapy directed at PD-1/PD-L1 has been widely employed, yielding positive results.

Synapse-to-synapse plasticity variability balanced to generate input-wide constancy of transmitter release.

Basal synaptic strength can vary greatly between synapses formed by an individual neuron because of diverse probabilities of action potential (AP) evoked transmitter release ( ). Optical quantal analysis on large numbers of identified larval glutamatergic synapses shows that short-term plasticity (STP) also varies greatly between synapses made by an individual type I motor neuron (MN) onto a single body wall muscle. Synapses with high and low and different forms and level of STP have a random spatial distribution in the MN nerve terminal, and ones with very different properties can be located within 200 nm of one other.