Publications by authors named "P R Ebeling"
Background: Parkinson's disease (PD) is the fastest-growing neurological disorder globally. Defining features include tremor, muscular rigidity, bradykinesia, and postural instability, which in combination with nonmotor symptoms such as cognitive impairment and orthostatic hypotension increase the risk of falls. Along with low bone mineral density, fracture risk is high in PD.
View Article and Find Full Text PDFOsteogenesis imperfecta (OI) is an uncommon bone disorder caused by mutations in type I collagen involved in bone matrix leading to increased fracture risk. There are several sub-categories within OI, with OI type I being the most common and mildest form. Women with OI considering pregnancy need to be aware of bone loss and fracture risk, particularly with lactation.
View Article and Find Full Text PDFContext: Although bone loss is a recognized consequence of premature ovarian insufficiency (POI), the impact on skeletal muscle health is less well-defined.
Objective: To compare muscle mass and function parameters between women with POI and controls.
Methods: Cross-sectional study from a tertiary health network and community between 2017 and 2023.
Unlabelled: Osteoporosis affects over half of older women, whether urban compared to rural residents have different risk of osteoporosis is unclear. This 23-year longitudinal study of Australian women found lower risk of osteoporosis and fractures among women living in rural compared with urban areas, which may relate to distribution of risk factors and/or screening opportunities.
Purpose: To determine whether the prevalence of osteoporosis, fractures, and dual-X-ray absorptiometry (DXA) differs between Australian women living in rural compared with urban areas.
Article Synopsis
- * Researchers studied a Caucasian family with a history of AFFs and identified a rare genetic variant in the LOXL4 gene that may be associated with increased susceptibility to these fractures.
- * The LOXL4 gene is involved in collagen production, and the variant may disrupt collagen metabolism, leading to microdamage in bones and poor healing, as indicated by tests on cells from affected individuals.