Publications by authors named "P R Deepa"
Article Synopsis
- A lot of people are getting metabolic syndrome, which can lead to a disease called non-alcoholic fatty liver disease (NAFLD) that happens when fat builds up in the liver.
- Researchers looked for drugs that can stop an enzyme called SCD1, which helps create fat in the liver, using a special database and computer models.
- They found that a drug called Montelukast seems to help lower fat in the liver and reduce damage caused by free radicals, suggesting it could be a good treatment for NAFLD.
Stearoyl-CoA desaturase 1 (SCD1) is one of the key enzymes involved in lipid metabolism, plays a vital role in the synthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Due to its promising therapeutic potential in treating metabolic disorders, cancers, and skin diseases there is an increasing interest in the development of novel inhibitors against SCD1. This review comprehensively explores the evolution of potential SCD1 inhibitors, focusing on systemic and liver-targeted inhibitors and discusses their structure-activity relationship (SAR) pattern.
View Article and Find Full Text PDFMastitis remains a paramount economic threat to dairy livestock, with antibiotic resistance severely compromising treatment efficacy. This study provides an in-depth investigation into the multidrug resistance (MDR) mechanisms in bacterial isolates from bovine mastitis, emphasizing the roles of antimicrobial resistance genes (ARGs), biofilm formation, and active efflux systems. A total of 162 Staphylococci, eight Escherichia coli, and seven Klebsiella spp.
View Article and Find Full Text PDFTherapeutic management of mastitis faces significant challenges due to multidrug resistance. In the present study, multi-drug-resistant (MDR) Staphylococcus spp, Klebsiella pneumoniae, and Escherichia coli were isolated from bovine clinical mastitis cases and the phenotypic and genotypic multidrug resistance profiling was carried out. Silver nanoparticles (AgNPs) were biosynthesized using Ocimum sanctum leaf extracts and characterized via UV Vis absorption, Fourier Transform Infrared Spectroscopy, X-ray diffraction studies, Energy dispersive spectroscopy and Electron Microscopy.
View Article and Find Full Text PDFArticle Synopsis
- Lumpy skin disease (LSD) is a virus affecting cattle, emerging rapidly in Asia and causing high rates of illness and death among livestock.
- Prior to 2019, India had no locally developed tools to manage LSD due to its absence, leading to the need for a cost-effective diagnostic solution.
- The study successfully created an indigenous indirect ELISA test that showed high accuracy (96.6% sensitivity and 95.1% specificity) for detecting antibodies against LSDV in cattle across different regions of India.