Publications by authors named "P R De"

The transmission of cytoskeletal forces to the extracellular matrix through focal adhesion complexes is essential for a multitude of biological processes, such as cell migration, cell differentiation, tissue development, and cancer progression, among others. During migration, focal adhesions arrest the actin retrograde flow towards the cell interior, allowing the cell front to move forward. Here, we address a puzzling observation of the existence of two distinct phenomena: a biphasic vs a monotonic relationship of the retrograde flow and cell traction force with substrate rigidity.

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Mitochondrial CPT1-mediated fatty acid β-oxidation (FAO) critically contributes to the accelerated metastatic expansion of triple negative breast cancer (TNBC). Hence, inhibition of FAO through active CPT1 targeting could be a promising therapeutic approach in anti-TNBC therapies. Herein, we strategically synthesized a pyrene chain end labelled copolymer bearing biotin pendants, CP4, that actively targets CPT1 and efficiently blocks FAO in metastatic TNBC.

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Understanding the formation of highly ordered structures through self-assembly is crucial for developing various biologically relevant systems. A significant expansion in the development of self-assembly chemistry features stable coassembly formation using a mixture of two oppositely charged polymers. This study provides insightful findings on the coassembly of hydrophobic coumarin-integrated cationic () and anionic () copolymers toward the formation of vesicles in aqueous medium at pH 7.

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Article Synopsis
  • Formaldehyde (FA) is a hazardous volatile organic compound that can harm human health, making it important to develop effective sensing technologies for monitoring it in the environment and industry.
  • This review focuses on various methodologies for FA sensing, emphasizing small molecules, nanoparticles, and especially polymers due to their superior capabilities.
  • The article aims to present recent advancements in polymeric FA sensors and outline future research directions to enhance their effectiveness and properties.
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