Publications by authors named "P R Corsi"
Article Synopsis
- - The study investigates the role of PD-L1 expression as a potential biomarker for bladder cancer by analyzing its presence in urine samples from patients undergoing surgical treatment for the disease.
- - Among 29 patients, PD-L1 expression rates varied significantly across tumor grades, with higher detection in high-grade tumors and good agreement between urine tests (cytoinclusion) and traditional tissue analysis (histopathology).
- - The research suggests cytoinclusion can serve as a promising, non-invasive method for assessing PD-L1 levels, potentially aiding in the diagnosis and prognosis of bladder cancer, and recommends further standardization for clinical use.
Cardiac involvement, such as myocarditis and pericarditis, can be a severe complication of monkeypox virus (mpox) infection and could be related to other co-infections with cardiac involvement. Tecovirimat is an antiviral specifically designed to inhibit smallpox infection diffusion and approved by the FDA for other Orthopoxvirus infections; its efficacy in mpox-infected patients is not well established. We present the case of a cardiac complication during mpox infection in a previously undiagnosed Lyme disease in a 42-year-old man living with HIV.
View Article and Find Full Text PDFThe urgency to find complementary therapies to current SARS-CoV-2 vaccines, whose effectiveness is preserved over time and not compromised by the emergence of new and emerging variants, has become a critical health challenge. We investigate the possibility of jamming the opening of the Receptor Binding Domain (RBD) of the spike protein of SARS-CoV-2 with small compounds. Through in silico screening, we identified two potential candidates that would lock the Receptor Binding Domain (RBD) in a closed configuration, preventing the virus from infecting the host cells.
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