Publications by authors named "P R Clapham"
Background: The United States Food and Drug Administration recently announced a national blood culture (BC) bottle shortage; the exact date of restoration is still being determined.
Aim: Implement a workflow to mitigate the BC bottle shortage at our hospital.
Methods: We created the following clinical decision support workflow in electronic medical record to help mitigate BC bottle use: (a) limit to two BC in 24 hours, (b) only repeat BC if 72 hours have passed from the prior sets, (c) do not repeat BC for coagulase-negative bacteremia when considered a contaminant (i.
For the 40 years after the end of commercial whaling in 1976, humpback whale populations in the North Pacific Ocean exhibited a prolonged period of recovery. Using mark-recapture methods on the largest individual photo-identification dataset ever assembled for a cetacean, we estimated annual ocean-basin-wide abundance for the species from 2002 through 2021. Trends in annual estimates describe strong post-whaling era population recovery from 16 875 (± 5955) in 2002 to a peak abundance estimate of 33 488 (± 4455) in 2012.
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- Understanding how different amino acids, particularly tryptophan at position 375, affect the HIV-1 envelope can improve vaccine development that triggers broadly neutralizing antibodies (bnAbs).
- The 375W mutation increases sensitivity to soluble CD4 and enhances macrophage infection in various HIV-1 envelope variants without affecting the neutralization capability of potent bnAbs.
- New findings suggest that there are different levels of macrophage tropism among HIV-1 variants, and targeting the 375W mutation in vaccines could help better expose the CD4 binding site while minimizing non-neutralizing responses.
Understanding the migratory patterns of large whales is of conservation importance, especially in identifying threats to specific populations. Migration ecology, including migratory destinations, movements and site fidelity for humpback whales (Megaptera novaeangliae) remain poorly studied in parts of the range of the Central America population, considered endangered under the United States Endangered Species Act. This study aimed to investigate the migratory destinations of humpback whales sighted at two study sites in Nicaragua, which are part of the Central America population.
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- * The dataset covers 13 regions and includes data on 27,956 unique humpback whales from 2001-2021, with an impressive identification accuracy of 97-99% using advanced machine learning.
- * This resource aims to facilitate collaborative research on humpback whales and their habitats, especially as the ocean undergoes significant ecological changes.