Reverse Shoulder Arthroplasty Implant Design and Configuration has a Significant Effect on Conjoint Tendon Impingement.

Background: Anterior shoulder pain after reverse shoulder arthroplasty (RSA) is not uncommon and may be due to humeral impingement against the conjoint tendon during internal rotation (IR). It is unknown what effect different implant designs and configurations have on conjoint tendon impingement. The purpose of this study was to investigate the influence of several RSA implant design parameters on conjoint tendon impingement during IR.

Mental Health Stigma Reduction Interventions Among Men: A Systematic Review.

Stigma surrounding mental health, particularly among men, remains a significant barrier to men engaging with support services for their mental health. Despite increasing evidence of interventions targeting different aspects of stigma reduction, there is a notable gap in the literature concerning male-specific mental health stigma reduction interventions and on the underlying behavior change techniques (BCTs) used to reduce stigma. The purpose of this review is to synthesize the evidence relating to the impact of mental health stigma reduction interventions among men and to explore the underlying BCTs associated with each intervention.

Pnictogen-based vanadacyclobutadiene complexes.

The reactivity of the V[triple bond, length as m-dash]C Bu multiple bonds in the complex (dBDI)V[triple bond, length as m-dash]C Bu(OEt) (C) (dBDI = ArNC(CH)CHC(CH)NAr, Ar = 2,6- PrCH) with unsaturated substrates such as N[triple bond, length as m-dash]CR (R = Ad or Ph) and P[triple bond, length as m-dash]CAd leads to the formation of rare 3d transition metal compounds featuring α-aza-vanadacyclobutadiene, (dBDI)V(κ- , - BuC(R)N) (R = Ad, 1; R = Ph, 2) and β-phospha-vanadacyclobutadiene moieties, (dBDI)V(κ- , - BuPAd) (3). Complexes 1-3 are characterized using multinuclear and multidimensional NMR spectroscopy, including the preparation of the 50% N-enriched isotopologue (dBDI)V(κ- , - BuCC(Ad)N) (1-N). Solid-state structural analysis is used to determine the dominant resonance structures of these unique pnictogen-based vanadacyclobutadienes.

FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia.

Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) is known to mediate these contradictory effects. Here, we show that the fms-like tyrosine kinase receptor 3 (FLT3) in peripheral somatosensory neurons drives morphine tolerance and hyperalgesia in a male rodent model.